Linear Immunoglobulin A Dermatosis-A Less Reported

Linear IgA disease (LAD) is a chronic, acquired, autoimmune bullous disease. Generalized bullous eruptions is not unusual in the intensive care unit. The cause can be idiopathic, autoimmune, or drug induced but prompt recognition is crucial to their management. The autoimmune blistering skin diseases are a heterogeneous group of diseases associated with autoantibodies that are directed against desmosomal structural proteins (in pemphigus diseases) or hemidesmosomal ones (in pemphigoid diseases and epidermolysis bullosa acquisita), or else against epidermal/tissue transglutaminases (dermatitis herpetiformis or LAD). Dermatitis herpetiformis (DH) and LAD are IgA mediated autoimmune bullous diseases and shares the same histopathology characters. They are differentiated based on the pattern of IgA deposition on direct immunofluorescence. Herein we describe an adult patient with LAD who recovered from LAD but later succumbed to secondary infections.